ALTUVIIIO® [Antihemophilic Factor (Recombinant), Fc-VWF-XTEN Fusion Protein-ehtl] logo
Purple and teal gradient background
Purple and teal gradient background

Hemophilia Education

Hemophilia and joint bleeds:
Preventing damage and
preserving your future mobility

Joint bleeds, often affecting the knees, elbows, ankles, or hips, are characteristic of hemophilia. These bleeds may be spontaneous or result from seemingly minor injuries. Find out more.

Purple and teal gradient background

More articles

3 teal outlined blood droplets graphic

Factor VIII is an important blood-clotting protein that is deficient or defective in individuals with hemophilia A. Find out more about Factor VIII deficiency.

Teal outlined blood cells graphic

Hemophilia A is classified as mild, moderate, or severe. But how is severity of hemophilia determined?

Teal outlined chromosomes and blood cells graphic

Hemophilia is a hereditary bleeding disorder affecting both men and women. What does it mean to be a hemophilia carrier?

Teal outlined doctor graphic

Preparing for your doctor appointment can play an important part in taking control of your hemophilia treatment and goals.

Teal outlined pregnant person graphic

Pregnancy can be challenging for women with hemophilia A, bringing unique risks to both the mother and her unborn baby. Women who are carriers of hemophilia or have hemophilia themselves face higher risk...

Teal outlined woman and girl silhouette graphic

Hemophilia A is a genetic bleeding disorder mostly seen in males, but it can also affect females who have hemophilia or carry the gene for it. Knowing the symptoms and how to manage them is very important for receiv...

Teal outlined test tube and magnifying glass graphic

PK testing to understand your factor activity levels is crucial for individuals or caregivers of people with hemophilia A. Knowing your Factor VIII levels helps you understand the severity of your condition and manage it be...

Teal outlined knee graphic

Target joints are joints where recurrent bleeding episodes occur, defined as having at least 3 or more spontaneous bleeds into a single joint within a consecutive 6-month period. These joints are more likely to get da...

Teal outlined blood droplet

Hemophilia is a genetic disorder that affects the blood's ability to clot, leading to prolonged bleeding. This condition varies widely in severity, which significantly impacts both the symptoms experienced and the da...

Hemophilia A signs and symptoms

Hemophilia A is a life-long bleeding disorder. If you or your child has hemophilia A, your body does not make enough of a clotting protein called Factor VIII. Factor VIII helps your blood form a clot to stop bleeding. Without enough Factor VIII, you may bleed more easily and for longer than usual.

Types of infusions for hemophilia A treatment: What patients and families need to know

Hemophilia A is a bleeding disorder caused by low levels of Factor VIII, a protein that helps blood clot properly. When Factor VIII is low, bleeding may last longer than normal and can sometimes occur inside the body—especially into joints or muscles. Many people manage hemophilia A by replacing missing ...


INDICATION
INDICATION
IMPORTANT SAFETY INFORMATION
INDICATION

ALTUVIIIO® [antihemophilic factor (recombinant), Fc-VWF-XTEN fusion protein-ehtl] is an injectable medicine that is used to control and reduce the number of bleeding episodes in people with hemophilia A (congenital Factor VIII deficiency).

Your healthcare provider may give you ALTUVIIIO when you have surgery.

IMPORTANT SAFETY INFORMATION

What is the most important information I need to know about ALTUVIIIO?

Do not attempt to give yourself an injection unless you have been taught how by your healthcare provider or hemophilia center. You must carefully follow your healthcare provider’s instructions regarding the dose and schedule for injecting ALTUVIIIO so that your treatment will work best for you.

Who should not use ALTUVIIIO?

You should not use ALTUVIIIO if you have had an allergic reaction to it in the past.

What should I tell my healthcare provider before using ALTUVIIIO?

Tell your healthcare provider if you have had any medical problems, take any medications, including prescription and non-prescription medicines, supplements, or herbal medicines, are breastfeeding, or are pregnant or planning to become pregnant.

What are the possible side effects of ALTUVIIIO?

You can have an allergic reaction to ALTUVIIIO. Call your healthcare provider or emergency department right away if you have any of the following symptoms: difficulty breathing, chest tightness, swelling of the face, rash, or hives.

Your body can also make antibodies called “inhibitors” against ALTUVIIIO. This can stop ALTUVIIIO from working properly. Your healthcare provider may give you blood tests to check for inhibitors.

The common side effects of ALTUVIIIO are headache and joint pain.

These are not the only possible side effects of ALTUVIIIO. Tell your healthcare provider about any side effect that bothers you or does not go away.

MAT-US-2406349-v4.0-05/2026 Last Updated: May 2026