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Understanding target joints and target joint resolution in hemophilia
What are target joints?
Defining target joints
Target joints are joints where recurrent bleeding episodes occur, defined as having at least 3 or more spontaneous bleeds into a single joint within a consecutive 6-month period. These joints, like knees, ankles, and elbows, are more likely to get damaged because they move a lot and carry weight. Understanding target joints in hemophilia is important for patients.
Common target joints
Target joints can be present in various parts of the body, but weight-bearing joints like the knees, ankles, and elbows are most at risk due to high levels of mobility and stress. Several factors contribute to the development of target joints in hemophilia, including the severity of hemophilia, frequent joint bleeds, age, body mass index (BMI), and the formation of inhibitors. Knowing these risk factors can help in managing and preventing further joint damage.
The impact of recurrent bleeding episodes on joint health
Consequences of repeated bleeding
Chronic bleeds into these joints can lead to synovitis, which is inflammation of the joint lining, causing pain, swelling, and reduced range of motion. This can lead to chronic pain and poor physical function. The resulting pain and mobility issues can significantly impact daily life. Patients should work with their doctor to manage joint bleeds.
How to achieve target joint resolution
Defining target joint resolution
Target joint resolution can help reduce the risk of progressive joint damage in people with hemophilia who are at risk of recurrent bleeding episodes. This involves a combination of treatment and management strategies aimed at preventing further bleeds and improving joint function.
Treatment and management strategies
There are several ways to help reduce the risk of bleeding and keep your joints healthy:
Follow doctor recommendations:
- Take all medications such as prophylactic Factor VIII replacement therapy as prescribed
- Attend all scheduled doctor visits for monitoring, joint assessments, and to talk about any concerns
- Take immediate action to address any signs of a joint bleed by getting rest and applying ice
Stay active:
- Talk to your healthcare provider before starting any exercise program
- Walk, swim, cycle on a stationary bike, or take part in other low-impact activities, which can help maintain and build muscle strength and joint mobility without putting stress on the joints
- Stay away from activities that put excessive stress on your joints, such as high-impact sports, heavy lifting, and repetitive motions
- Consider working with a physical therapist who can develop a personalized exercise routine that focuses on range of motion, flexibility, and strength
This article is for general educational purposes only. Please talk to your doctor if you have any questions about your health or treatment.
Frequently asked questions on target joints and joint health
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ALTUVIIIO® [antihemophilic factor (recombinant), Fc-VWF-XTEN fusion protein-ehtl] is an injectable medicine that is used to control and reduce the number of bleeding episodes in people with hemophilia A (congenital Factor VIII deficiency).
Your healthcare provider may give you ALTUVIIIO when you have surgery.
What is the most important information I need to know about ALTUVIIIO?
Do not attempt to give yourself an injection unless you have been taught how by your healthcare provider or hemophilia center. You must carefully follow your healthcare provider’s instructions regarding the dose and schedule for injecting ALTUVIIIO so that your treatment will work best for you.
Who should not use ALTUVIIIO?
You should not use ALTUVIIIO if you have had an allergic reaction to it in the past.
What should I tell my healthcare provider before using ALTUVIIIO?
Tell your healthcare provider if you have had any medical problems, take any medications, including prescription and non-prescription medicines, supplements, or herbal medicines, are breastfeeding, or are pregnant or planning to become pregnant.
What are the possible side effects of ALTUVIIIO?
You can have an allergic reaction to ALTUVIIIO. Call your healthcare provider or emergency department right away if you have any of the following symptoms: difficulty breathing, chest tightness, swelling of the face, rash, or hives.
Your body can also make antibodies called “inhibitors” against ALTUVIIIO. This can stop ALTUVIIIO from working properly. Your healthcare provider may give you blood tests to check for inhibitors.
The common side effects of ALTUVIIIO are headache and joint pain.
These are not the only possible side effects of ALTUVIIIO. Tell your healthcare provider about any side effect that bothers you or does not go away.
Please see full Prescribing Information.
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