Man lifting dumbbells in the gym and doing leg exercises
Man lifting dumbbells in the gym and doing leg exercises
Factor VIII levels at 43%, 4 days after infusion
Hypothetical patient and scenario
Factor VIII levels at 43%, 4 days after infusion
Hypothetical patient and scenario

Engineered to last longer

Watch how ALTUVIIIO works

The unique design of ALTUVIIIO keeps factor levels higher for longer

Infographic shows how ALTUVIIIO combines three component to help keep factor levels higher in the body for longer.  Fc Fusion helps Factor VIII recirculate in your blood. XTEN Technology shields Factor VIII from breaking down too early. vWF Fragments keeps Factor VIII in your blood for longer.
vWF=von Willebrand Factor.

How exactly does ALTUVIIIO work in the body?

ALTUVIIIO uniquely combines 3 components to help it stay in your body longer: Fc region of IgG, XTEN Technology, and vWF Fragments. All 3 components work together to release rFVIII so it can stop the bleed.

ALTUVIIIO uniquely combines 3 components to help it stay in your body longer: Fc region of IgG, XTEN Technology, and vWF Fragments. All 3 components work together to release rFVIII so it can stop the bleed.

Infographic shows how Factor VIII in ALTUVIIIO is already bound to fragments of von Willebrand Factor, keeping it from binding to natural von Willebrand Factor in the bloodstream. This helps to sustain ALTUVIIIO in the body for longer.
Step 1
Sustain
The Factor VIII in ALTUVIIIO is already bound to fragments of von Willebrand Factor, keeping it from binding to natural von Willebrand Factor in the bloodstream. This helps to sustain ALTUVIIIO in the body for longer.
Infographic shows how XTEN Technology also protects ALTUVIIIO from being broken down. When a bleed occurs, the XTEN chains release the von Willebrand Factor fragments, activating ALTUVIIIO to promote clotting
Step 2
Protect
XTEN Technology also protects ALTUVIIIO from being broken down. When a bleed occurs, the XTEN chains release the von Willebrand Factor fragments, activating ALTUVIIIO to promote clotting.
Infographic shows how The Fc protein helps to redirect ALTUVIIIO back into the bloodstream, preventing it from being broken down inside the cell and allowing it to circulate for longer.
Step 3
Redirect
The Fc protein helps to redirect ALTUVIIIO back into the bloodstream, preventing it from being broken down inside the cell and allowing it to circulate for longer.
IgG=immunoglobulin G; rFVIII=recombinant Factor VIII.
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Sanofi Hemophilia Community Relations and Education (CoRe) Managers offer education to people living with hemophilia and their families. CoRe Managers provide information about living with hemophilia and treatment options. Use our handy CoRe Locator to find the CoRe team member nearest you.
Altuviiio branding design