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For Healthcare Professionals
Prescribing Information
Instructions For Use
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Factor VIII levels at 43%, 4 days after infusion
Hypothetical patient and scenario
Factor VIII levels at 43%, 4 days after infusion
Hypothetical patient and scenario

Engineered to last longer

Watch how ALTUVIIIO works

The unique design of ALTUVIIIO keeps factor levels higher for longer

Infographic shows how ALTUVIIIO combines 3 components to help keep factor levels higher in the body for longer. Fc Fusion helps Factor VIII recirculate in your blood. XTEN Technology shields Factor VIII from breaking down too early. vWF Fragments keeps Factor VIII in your blood for longer.
vWF=von Willebrand Factor.

How exactly does ALTUVIIIO work in the body?

ALTUVIIIO uniquely combines 3 components to help it stay in your body longer: Fc region of IgG, XTEN Technology, and vWF Fragments. All 3 components work together to release rFVIII so it can stop the bleed.

ALTUVIIIO uniquely combines 3 components to help it stay in your body longer: Fc region of IgG, XTEN Technology, and vWF Fragments. All 3 components work together to release rFVIII so it can stop the bleed.

Graphic shows how Factor VIII in ALTUVIIIO is already bound to fragments of von Willebrand Factor, keeping it from binding to natural von Willebrand Factor in the bloodstream. This helps to sustain ALTUVIIIO in the body for longer.
Step 1
Sustain
The Factor VIII in ALTUVIIIO is already bound to fragments of von Willebrand Factor, keeping it from binding to natural von Willebrand Factor in the bloodstream. This helps to sustain ALTUVIIIO in the body for longer.
Graphic shows how XTEN Technology also protects ALTUVIIIO from being broken down. When a bleed occurs, the XTEN chains release the von Willebrand Factor fragments, activating ALTUVIIIO to promote clotting
Step 2
Protect
XTEN Technology also protects ALTUVIIIO from being broken down. When a bleed occurs, the XTEN chains release the von Willebrand Factor fragments, activating ALTUVIIIO to promote clotting.
Graphic shows how The Fc protein helps to redirect ALTUVIIIO back into the bloodstream, preventing it from being broken down inside the cell and allowing it to circulate for longer
Step 3
Redirect
The Fc protein helps to redirect ALTUVIIIO back into the bloodstream, preventing it from being broken down inside the cell and allowing it to circulate for longer.
IgG=immunoglobulin G; rFVIII=recombinant Factor VIII.
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Indication
ALTUVIIIO® [antihemophilic factor (recombinant), Fc-VWF-XTEN fusion protein-ehtl] is an injectable medicine that is used to control and reduce the number of bleeding episodes in people with hemophilia A (congenital Factor VIII deficiency). Your healthcare provider may give you ALTUVIIIO when you have surgery.
Important safety information
What is the most important information I need to know about ALTUVIIIO?
Do not attempt to give yourself an injection unless you have been taught how by your healthcare provider or hemophilia center. You must carefully follow your healthcare provider’s instructions regarding the dose and schedule for injecting ALTUVIIIO so that your treatment will work best for you.
Who should not use ALTUVIIIO?
You should not use ALTUVIIIO if you have had an allergic reaction to it in the past.
What should I tell my healthcare provider before using ALTUVIIIO?
Tell your healthcare provider if you have had any medical problems, take any medications, including prescription and non-prescription medicines, supplements, or herbal medicines, are breastfeeding, or are pregnant or planning to become pregnant.
What are the possible side effects of ALTUVIIIO?
You can have an allergic reaction to ALTUVIIIO. Call your healthcare provider or emergency department right away if you have any of the following symptoms: difficulty breathing, chest tightness, swelling of the face, rash, or hives. Your body can also make antibodies called “inhibitors” against ALTUVIIIO. This can stop ALTUVIIIO from working properly. Your healthcare provider may give you blood tests to check for inhibitors. The common side effects of ALTUVIIIO are headache, joint pain, and back pain. These are not the only possible side effects of ALTUVIIIO. Tell your healthcare provider about any side effect that bothers you or does not go away.
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Prescribing Information.
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