In hemophilia A, Factor VIII is either
missing or not working properly
When an injury causes a bleed, a process called hemostasis occurs at the injury site to form a clot and stop the bleed
Hemostasis is achieved in 2 parts:
- Primary hemostasis: Platelets are recruited to the site of the injury and, with the help of von Willebrand Factor (vWF), create a “platelet plug” to reduce blood loss
- Secondary hemostasis: This is where the multistep clotting cascade is activated to form a fibrin mesh around the platelets to stabilize the clot
Without enough Factor VIII, your body’s ability to generate thrombin is reduced, meaning:
Blood cannot clot properly
Excessive bleeding can occur
The amount of Factor VIII in your blood is called your “factor activity level”
Everyone’s factor activity levels are different. People with lower factor levels have greater bleed risk, and people with higher factor activity levels have better protection. Every person has unique treatment goals. That’s why it’s important to talk to your doctor about managing your hemophilia.
Keeping factor levels up with prophylaxis treatment will help provide better protection against bleeds
Factor levels can impact lifestyle and activity
The more factor you have in your body, the better your bleed protection is, which is why many people with hemophilia choose prophylaxis treatment.
- There is a high risk of spontaneous bleeds and pain with target joints
- Supplemental factor is needed for surgery
*WFH Guidelines define the upper limit of mild hemophilia as 40% factor activity and the WFH Introduction to Hemophilia defines the normal range as 50% to 150%, which indicates that 40% to 50% would be in between mild hemophilia and normal, here referred to as “near-normal” levels.
WFH=World Federation of Hemophilia.
People with hemophilia take prophylaxis treatments, or preventative treatments, to help keep their factor levels higher to reduce the risk of a bleed
For people treating on-demand, treatment increases their factor levels and restores hemostasis after a bleed occurs.
Connect With a CoRe Manager
Sanofi Hemophilia Community Relations and Education (CoRe) Managers offer education to people living with hemophilia and their families. CoRe Managers provide information about living with hemophilia and treatment options. Use our handy CoRe Locator to find the CoRe team member nearest you.
Get Informed. Stay Informed.
Let’s stay in touch. We’ll occasionally send you important information on hemophilia A and ALTUVIIIO.